Project

# Title Team Members TA Documents Sponsor
33 Autologous Transcranial Implant for the Delivery of Photodynamic Therapy for Intracranial Brain Tumors
 Brian Diner
Jack Stender
Mohamed Belakhoua
 Sarath Saroj design_document1.pdf
final_paper1.pdf
proposal1.pdf
video
# Autologous Transcranial Implant for the Delivery of Photodynamic Therapy for Intracranial Brain Tumors

Team Members:
- Jack Stender (stender3)
- Mohamed Belakhoua (mab21)
- Brian Diner (bdiner2)

# Problem

Glioblastoma has a very poor prognosis of 12-15 months post-operation. The current standard of treatment is surgical resection, radiation therapy, and chemotherapy. There exists one FDA-approved device on the market that attempts to solve a similar problem - Optune. Other alternatives exist as well but they have low efficacy overall. In recent trials, photodynamic therapy has proven effective in treating cancerous cells though currently it can only be administered mid-surgery while the brain is exposed.

# Solution

To allow for photodynamic therapy to be administered post-operatively, we propose developing a small transcranial implant that would provide the light source for this therapy. Our objective is to create a programmable device that can be implanted through the skull which will provide control over PDT delivery chronically, allowing patients with GBM to be photo-irradiated without re-entering the operating room after their resection is completed. Components of this transcranial implant would include the appropriate light source, a light diffuser, battery, and an on/off mechanism.


# Solution Components

## Light Source / Light Diffuser

- Medical grade titanium socket implant attached to the skull.
- Medical grade resin printed LED diffuser sitting in metal socket. Similar size to an apple watch in all dimensions

## Battery

- Single-use battery - taking cues from pacemaker design

## On/off Mechanism

- RFID or bluetooth code transmission to the microcontroller determines when and how LEDs are on

# Criterion For Success

Create a working prototype of a Photodynamic Therapeutic device. Create a custom PCB for an LED diode array that can be remotely programmed for the duration and intensity of the light. Design and implement a 3D-printed casing in the dimensions of the final product.

Electronic Mouse (Cat Toy)

Jack Casey, Chuangy Zhang, Yingyu Zhang

Electronic Mouse (Cat Toy)

Featured Project

# Electronic Mouse (Cat Toy)

# Team Members:

- Yingyu Zhang (yzhan290)

- Chuangy Zhang (czhan30)

- Jack (John) Casey (jpcasey2)

# Problem Components:

Keeping up with the high energy drive of some cats can often be overwhelming for owners who often choose these pets because of their low maintenance compared to other animals. There is an increasing number of cats being used for service and emotional support animals, and with this, there is a need for an interactive cat toy with greater accessibility.

1. Get cats the enrichment they need

1. Get cats to chase the “mouse” around

1. Get cats fascinated by the “mouse”

1. Keep cats busy

1. Fulfill the need for cats’ hunting behaviors

1. Interactive fun between the cat and cat owner

1. Solve the shortcomings of electronic-remote-control-mouses that are out in the market

## Comparison with existing products

- Hexbug Mouse Robotic Cat Toy: Battery endurance is very low; For hard floors only

- GiGwi Interactive Cat Toy Mouse: Does not work on the carpet; Not sensitive to cat touch; Battery endurance is very low; Can't control remotely

# Solution

A remote-controlled cat toy is a solution that allows more cat owners to get interactive playtime with their pets. With our design, there will be no need to get low to the ground to adjust it often as it will go over most floor surfaces and in any direction with help from a strong motor and servos that won’t break from wall or cat impact. To prevent damage to household objects it will have IR sensors and accelerometers for use in self-driving modes. The toy will be run and powered by a Bluetooth microcontroller and a strong rechargeable battery to ensure playtime for hours.

## Subsystem 1 - Infrared(IR) Sensors & Accelerometer sensor

- IR sensors work with radar technology and they both emit and receive Infrared radiation. This kind of sensor has been used widely to detect nearby objects. We will use the IR sensors to detect if the mouse is surrounded by any obstacles.

- An accelerometer sensor measures the acceleration of any object in its rest frame. This kind of sensor has been used widely to capture the intensity of physical activities. We will use this sensor to detect if cats are playing with the mouse.

## Subsystem 2 - Microcontroller(ESP32)

- ESP32 is a dual-core microcontroller with integrated Wi-Fi and Bluetooth. This MCU has 520 KB of SRAM, 34 programmable GPIOs, 802.11 Wi-Fi, Bluetooth v4.2, and much more. This powerful microcontroller enables us to develop more powerful software and hardware and provides a lot of flexibility compared to ATMegaxxx.

Components(TBD):

- Product: [https://www.digikey.com/en/products/detail/espressif-systems/ESP32-WROOM-32/8544298](url)

- Datasheet: [http://esp32.net](url)

## Subsystem 3 - App

- We will develop an App that can remotely control the mouse.

1. Control the mouse to either move forward, backward, left, or right.

1. Turn on / off / flashing the LED eyes of the mouse

1. keep the cat owner informed about the battery level of the mouse

1. Change “modes”: (a). keep running randomly without stopping; (b). the cat activates the mouse; (c). runs in cycles(runs, stops, runs, stops…) intermittently (mouse hesitates to get cat’s curiosity up); (d). Turn OFF (completely)

## Subsystem 4 - Motors and Servo

- To enable maneuverability in all directions, we are planning to use 1 servo and 2 motors to drive the robotic mouse. The servo is used to control the direction of the mouse. Wheels will be directly mounted onto motors via hubs.

Components(TBD):

- Metal Gear Motors: [https://www.adafruit.com/product/3802](url)

- L9110H H-Bridge Motor Driver: [https://www.adafruit.com/product/4489](url)

## Subsystem 5 - Power Management

- We are planning to use a high capacity (5 Ah - 10 Ah), 3.7 volts lithium polymer battery to enable the long-last usage of the robotic mouse. Also, we are using the USB lithium polymer ion charging circuit to charge the battery.

Components(TBD):

- Lithium Polymer Ion Battery: [https://www.adafruit.com/product/5035](url)

- USB Lithium Polymer Ion Charger: [https://www.adafruit.com/product/259](url)

# Criterion for Success

1. Can go on tile, wood, AND carpet and alternate

1. Has a charge that lasts more than 10 min

1. Is maneuverable in all directions(not just forward and backward)

1. Can be controlled via remote (App)

1. Has a “cat-attractor”(feathers, string, ribbon, inner catnip, etc.) either attached to it or drags it behind (attractive appearance for cats)

1. Retains signal for at least 15 ft away

1. Eyes flash

1. Goes dormant when caught/touched by the cats (or when it bumps into something), reactivates (and changes direction) after a certain amount of time

1. all the “modes” worked as intended

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