Instructor
Sergei Maslov: maslov@illinois.edu
Office: IGB 3406
Office hours: by appointment
Teaching Assistant
Anoosha Tahir: at78@illinois.edu
Office hours: by appointment
Hours
Tuesdays: 9:30AM - 10:50AM
Thursdays: 9:30AM - 10:50AM
Location
4029 Campus Instructional Facility
Laptop computers with Matlab Installed
You will need a laptop in this class. Laptops need to have Matlab installed with Bioinformatics and Statistics & Machine Learning toolboxes.
An alternative to buying Matlab is to use CITRIX for UIUC students and connect to EWS Windows Lab Software.
iClickers
I would like you all to have an iClicker and bring it to every class. On amazon.com a new iClicker costs around $40. It is also sold at UIUC Bookstore. Used ones are cheaper.
An alternative solution is using a mobile or desktop app: https://www.iclicker.com/students/apps-and-remotes/apps
Your answers WILL NOT be used for grading. I need them to see if I lost some of you and what could I rephrase to better explain the material
Description
The course will provide students with fundamental knowledge and techniques in
computational bioengineering, focusing on statistical methods, including:
- basic concepts of probability, Bayes theorem
- discrete and continuous probability distributions
- multivariate statistics
- sampling distributions
- parameter estimation
- confidence intervals
- hypothesis testing
- regression
Statistics methods will be illustrated using examples from
genomics & systems biology:
- genome assembly
- gene expression and proteomics data
- biological networks
Suggested Textbooks
- Montgomery, DC and Runger, GC: Applied Statistics and Probability for Engineers, 4th to 6th Edition. John Wiley & Sons, Inc.
4th edition (2007), 5th edition (2011), 6th edition (2014)
5th edition is available online
- Montgomery, DC and Runger, GC: Student Solutions Manual Applied Statistics and Probability for Engineers, 4th to 6th Edition. John Wiley & Sons, Inc.
4th edition (2007), 5th edition (2011), 6th edition (2014)
5th edition is available online
- Ewens, WJ and Grant, GR: Statistical Methods in Bioinformatics: An Introduction,
2nd ed, Springer, (2005)
Available online
- Vidakovic, B: Statistics for Bioengineering Sciences with MATLAB and WinBUGS Support
(2011) Springer, New York
The book is free as PDF download and is constantly updated with the newest version at: http://statbook.gatech.edu/statb4.pdf
Matlab exercises and datasets are at http://springer.bme.gatech.edu
Author is a Professor at the Department of Biomedical Engineering, Georgia Tech
- Pevsner J, Bioinformatics and functional genomics,
Wiley-Blackwell,
The 2nd edition (2009) is available online
I recommend the 3rd edition (2015) has lots of up-to-date information on Next Generation Sequencing
Syllabus written and maintained by Prof. Sergei Maslov
Department of Bioengineering
University of Illinois at Urbana-Champaign
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Academic Integrity
The University of Illinois at Urbana-Champaign Student Code should also be considered as a part of this syllabus. Students should pay particular attention to Article 1, Part 4: Academic Integrity. Read the Code at the following URL: http://studentcode.illinois.edu/.
Academic dishonesty will result in a sanction proportionate to the severity of the infraction, with possible sanctions described in 1-404 of the Student Code (https://studentcode.illinois.edu/article1/part4/1-404/). Every student is expected to review and abide by the Academic Integrity Policy as defined in the Student Code: https://studentcode.illinois.edu/article1/part4/1-401/. As a student it is your responsibility to refrain from infractions of academic integrity and from conduct that aids others in such infractions. A short guide to academic integrity issues may be found at https://provost.illinois.edu/policies/policies/academic-integrity/students-quick-reference-guide-to-academic-integrity/. Ignorance of these policies is not an excuse for any academic dishonesty. It is your responsibility to read this policy to avoid any misunderstanding. Do not hesitate to ask the instructor(s) if you are ever in doubt about what constitutes plagiarism, cheating, or any other breach of academic integrity.
Anti-Racism and Inclusivity Statement
The Grainger College of Engineering is committed to the creation of an anti-racist, inclusive community that welcomes diversity along a number of dimensions, including, but not limited to, race, ethnicity and national origins, gender and gender identity, sexuality, disability status, class, age, or religious beliefs. The College recognizes that we are learning together in the midst of the Black Lives Matter movement, that Black, Hispanic, and Indigenous voices and contributions have largely either been excluded from, or not recognized in, science and engineering, and that both overt racism and micro-aggressions threaten the well-being of our students and our university community.
The effectiveness of this course is dependent upon each of us to create a safe and encouraging learning environment that allows for the open exchange of ideas while also ensuring equitable opportunities and respect for all of us. Everyone is expected to help establish and maintain an environment where students, staff, and faculty can contribute without fear of personal ridicule, or intolerant or offensive language. If you witness or experience racism, discrimination, micro-aggressions, or other offensive behavior, you are encouraged to bring this to the attention of the course director if you feel comfortable. You can also report these behaviors to the Bias Assessment and Response Team (BART) (https://bart.illinois.edu/). Based on your report, BART members will follow up and reach out to students to make sure they have the support they need to be healthy and safe. If the reported behavior also violates university policy, staff in the Office for Student Conflict Resolution may respond as well and will take appropriate action.
Mental Health and Wellness
Diminished mental health, including significant stress, mood changes, excessive worry, substance/alcohol abuse, or problems with eating and/or sleeping can interfere with optimal academic performance, social development, and emotional wellbeing. The University of Illinois offers a variety of confidential services including individual and group counseling, crisis intervention, psychiatric services, and specialized screenings at no additional cost. If you or someone you know experiences any of the above mental health concerns, it is strongly encouraged to contact or visit any of the University’s resources provided below. Getting help is a smart and courageous thing to do – for yourself and for those who care about you.
Counseling Center: 217-333-3704, 610 East John Street Champaign, IL 61820
McKinley Health Center: 217-333-2700, 1109 South Lincoln Avenue, Urbana, Illinois 61801